Henderson's versatile talents can be heard throughout the Brunswick Records catalog as well as a myriad of sides recorded during the '60s-'70s heydays of Chicago soul. Born August 9, 1941, in Pensacola, FL, Henderson's family moved to Chicago when he was a child. Taking up the baritone sax, he began backing Otis Rush and others while in his twenties. He also studied with another arranging legend, James Mack. After graduating from College, Henderson began playing around Chicago, backing Syl Johnson, Alvin Cash, and Harold Burrage. He joined the Chicago division of N.Y.-based Brunswick Records in 1968. Working with producer Carl Davis, Henderson arranged, produced, and played on records by the Chi-Lites, Jackie Wilson, Tyrone Davis, Barbara Acklin, and other Brunswick acts.
In 1974, Henderson left Brunswick to become an independent producer. He continued working throughout the 70's, and during the 80's he released singles on his Now Sound label. By 1999, he had formed the Chicago Music Organization and continues to produce, arrange, and occasionally perform with a band.